The General Secretariat of the OWHC relies on the support of a network of 7 Regional Secretariats throughout the world. Based in different member cities of the OWHC the primary mission of the Regional Secretariats is to serve as a link between the member cities of their particular region and the General Secretariat. Their main goals are:
- grouping together cities that share cultural, linguistic or geographic affinities;
- assisting the General Secretariat in producing documents intended for members, data collection and the organization of relevant events;
- representing, when necessary, the General Secretariat at events in which the latter is invited to participate;
- organizing in their regions activities intended to promote the Organization's values and objectives.