The primary mission of the Regional Secretariats is to serve as a link between the member cities of their particular region and the General Secretariat. Their main goals are:

• grouping together cities that share cultural, linguistic or geographic affinities;
• assisting the General Secretariat in producing documents intended for members, data collection and the organization of relevant events;
• representing, when necessary, the General Secretariat at events in which the latter is invited to participate;
• organizing in their regions activities intended to promote the Organization's values and objectives.